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BRAND NAME-FEOFER 2.5 TABLETS

COMPOSITION- LETROZOLE 2.5 MG TABLETS

PACKING-10*5 TABLETS

??  LETROZOLE is an oral non-steroidal type II  aromatase inhibitor.(third generation).

??  a potential ovulation induction (OI) drug.

??  good option, with its oral route of administration, cost, shorter half-life and negligible side effects. 

??  in women with failure or resistance to Clomiphene citrate, letrozole was shown to be very effective both in ovulation rate and live birth rate.

??  MECHANISM OF LETROZOLE

??  blocks the conversion of androgens to estrogens in the ovarian follicles, peripheral tissues, and in the brain—

??   1) FALL IN CIRCULATING  & LOCAL ESTROGENS-- Release hypothalamopituitary axis from negative feedback of estrogens--FSH release-- OVULATION

??   2) RISE IN INTRAOVARIAN ANDROGENS--increased follicular sensitivity to fsh hormone--OVULATION

Advantages of aromatase inhibitor over Clomiphene citrate:

??  It does not deplete estrogen receptors (ER) throughout the body

??  It keeps the hypothalamopituitary axis intact

??  It is short acting (45 min half-life).

INDICATIONS

1.     Ovarian induction in polycystic ovary syndrome (PCOS)

2.     Ovarian induction in intrauterine insemination (IUI)

3.     Ovarian stimulation for IVF/ICSI.

Additional Information:

• Packaging Details: 10*5 blister

Product Details: